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Beilstein J. Org. Chem. 2019, 15, 852–857, doi:10.3762/bjoc.15.82
Graphical Abstract
Scheme 1: Synthesis of amino acid-based isocyanides starting from α-amino acids.
Scheme 2: Synthesis of pseudo-peptides using levulinic acid, isocyanide esters and amines.
Figure 1: Synthesis of functionalized 5-membered lactams using Ugi reaction. aIsolated yield for mixture of d...
Scheme 3: Proposed mechanism for Ugi-4C-3CR.
Figure 2: ORTEP representation of compound (R*,S*)-4a with thermal ellipsoids at 50% probability. Opposite en...